The product is consists of dehydrated cells of Enterococcus faecium NCIMB 10415. It has current EU approval for use in feed for chickens, turkeys and pigs for fattening, as well as piglets, sows, calves, cats and dogs.
The EU risk assessor’s FEEDAP Panel estimates that, based on a tolerance study in chickens for fattening in which no adverse effects were seen when Cylactin was supplemented at 100 times the recommended dose, the product is safe for use in feed for the additional poultry species requested.
Coccidiostat compatibility
DSM had also been seeking an amendment of the terms of the current authorization for chickens for fattening to allow simultaneous use of E. faecium NCIMB 10415 with a list of coccidiostats.
It previously provided an in vivo trial with chickens for fattening to show compatibility of the active agent of Cylactin with lasalocid, maduramycin ammonium, narasin, narasin/nicarbazin and salinomycin.
However, EFSA said flaws in the experimental design of that study prevented it from drawing a robust conclusion on whether such compatibility claims were sound.
But, based on a new in vivo study DSM subsequently submitted, the Panel has now found E. faecium NCIMB 10415 can be used in conjunction with those particular coccidiostats.
The nutrition company also provide new data on the stability of the additive during pelleting of poultry feed, with EFSA confirming that the two forms of the product, LBC ME10 and LBC ME20, are stable at pelleting temperatures up to 85 and 95°C, respectively.
The full FEEDAP Panel's opinion can be read here.
Crina Poultry Plus
In another opinion this month, the Parma based risk assessor also determined that the Dutch group’s feed ingredient, Crina Poultry Plus, which is a mixture of benzoic acid, thymol, eugenol and piperine, has “some potential to be efficacious” in chickens for fattening at a dose of 300 mg per kilogram of complete feed.
It said the same conclusions could be drawn on its effectiveness in chickens reared for laying and minor poultry species for fattening and reared for laying at the same dose.
In a previous assessment, the FEEDAP Panel had not been able to conclude on the safety of the additive for chickens for fattening, the consumer nor the environment.
It also could not determine the efficacy of Crina Poultry Plus in its 2012 opinion but DSM sent in additional data to the assessment body in a bid to get a positive opinion for the poultry feed ingredient, in particular two new trials said to support its efficacy claims.