Liver is one of the important organs in pigs. It has the functions of nutritional metabolism, detoxification, digestion and immunity, and 85% of pig diseases are related to liver damage. Yeast nucleotide (GroPro) plays an important role in preventing liver damage and ensuring normal liver function. Supplementing exogenous nucleotides for sows and piglets can not only improve the fecundity of sows and reduce liver damage, but also ensure the normal liver function of piglets and reduce the incidence of diseases.